# FAM174B

Source: https://onco.cc/targets/fam174b/  
OnCo record `fam174b` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FAM174B (Membrane protein FAM174B) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Medulloblastoma and Paediatric low-grade glioma.

## Summary

Essential for Golgi structural integrity.

IntOGen calls it a driver in 3 cohorts (3 activating, 0 loss-of-function), covering Medulloblastoma, Pilocytic Astrocytoma, Prostate Adenocarcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: family with sequence similarity 174 member B; Membrane protein FAM174B; LOC400451; MGC102891
- Tags: cancer-genes-wave
- Symbol: FAM174B
- Class: oncogene
- Biology: Essential for Golgi structural integrity. Location: Cell membrane; Golgi apparatus (UniProt). Locus 15q26.1 (HGNC).
- Where found: Prostate cancer: IntOGen driver in 1 cohort (PRAD); Medulloblastoma: IntOGen driver in 1 cohort (MBL); Paediatric low-grade glioma: IntOGen driver in 1 cohort (PAST)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 3 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:34339: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:34339
- UniProt Q3ZCQ3: https://www.uniprot.org/uniprotkb/Q3ZCQ3/entry
- NCBI Gene 400451: https://www.ncbi.nlm.nih.gov/gene/400451
- Ensembl ENSG00000185442: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000185442

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Medulloblastoma](https://onco.cc/cancers/medulloblastoma/), [Paediatric low-grade glioma](https://onco.cc/cancers/paediatric-low-grade-glioma/), [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/fam174b.json