# FANCB

Source: https://onco.cc/targets/fancb/  
OnCo record `fancb` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FANCB (Fanconi anaemia group B protein) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.

## Summary

DNA repair protein required for FANCD2 ubiquitination.

Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.72, genetic association 0.18, genetic literature 0.83).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: FA complementation group B; Fanconi anemia group B protein; FLJ34064; FAAP95
- Tags: cancer-genes-wave
- Symbol: FANCB
- Class: other
- Biology: DNA repair protein required for FANCD2 ubiquitination. Location: Nucleus (UniProt). Locus Xp22.2 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword "DNA repair". Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3583: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3583
- UniProt Q8NB91: https://www.uniprot.org/uniprotkb/Q8NB91/entry
- NCBI Gene 2187: https://www.ncbi.nlm.nih.gov/gene/2187
- Ensembl ENSG00000181544: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000181544

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/fancb.json