# FANCC

Source: https://onco.cc/targets/fancc/  
OnCo record `fancc` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FANCC (Fanconi anaemia group C protein) is a gene. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Leukaemia, Pancreatic ductal adenocarcinoma and 5 more.

## Summary

DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Gemcitabine, Mitomycin, Cisplatin and Chlorambucil and others. Open Targets scores its association with cancer at 0.80 (direct and indirect evidence; datatypes genetic literature 0.85, affected pathway 0.76, literature 0.89, genetic association 0.68, somatic mutation 0.98).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: FA complementation group C; Fanconi anemia group C protein; FA3
- Tags: cancer-genes-wave
- Symbol: FANCC
- Class: other
- Biology: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. Location: Nucleus; Cytoplasm (UniProt). Locus 9q22.32 (HGNC).
- Where found: Breast cancer: Open Targets association 0.65 with breast cancer (MONDO_0007254); Leukaemia: Open Targets association 0.63 with leukaemia (MONDO_0005059); Pancreatic ductal adenocarcinoma: CIViC evidence names this disease; Ovarian cancer: Open Targets association 0.56 with ovarian cancer (MONDO_0008170); Colorectal cancer: Open Targets association 0.56 with colorectal cancer (MONDO_0005575); Myeloproliferative neoplasms: Open Targets association 0.54 with myeloproliferative neoplasm (MONDO_0020076)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 5 therapies; CIViC holds 1 clinical evidence items on its variants; UniProt keyword "DNA repair". Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3584: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3584
- UniProt Q00597: https://www.uniprot.org/uniprotkb/Q00597/entry
- NCBI Gene 2176: https://www.ncbi.nlm.nih.gov/gene/2176
- Ensembl ENSG00000158169: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000158169

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Acute myeloid leukaemia](https://onco.cc/cancers/aml/), [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Myelodysplastic syndromes / neoplasms (MDS)](https://onco.cc/cancers/mds/), [Myeloproliferative neoplasms (PV, ET, myelofibrosis)](https://onco.cc/cancers/myeloproliferative-neoplasms/), [Ovarian cancer](https://onco.cc/cancers/ovarian/), [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/)

---
JSON: https://onco.cc/api/v1/entities/fancc.json