# FANCD2

Source: https://onco.cc/targets/fancd2/  
OnCo record `fancd2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FANCD2 (Fanconi anaemia group D2 protein) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Leukaemia, Myeloproliferative neoplasms, Breast cancer and 5 more.

## Summary

Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing.

Open Targets scores its association with cancer at 0.83 (direct and indirect evidence; datatypes genetic literature 0.89, affected pathway 0.27, literature 0.97, genetic association 0.75, somatic mutation 0.90, animal model 0.37).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: FA complementation group D2; Fanconi anemia group D2 protein; FA-D2; FANCD
- Tags: cancer-genes-wave
- Symbol: FANCD2
- Class: other
- Biology: Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Location: Nucleus (UniProt). Locus 3p25.3 (HGNC).
- Where found: Leukaemia: Open Targets association 0.70 with leukaemia (MONDO_0005059); Myeloproliferative neoplasms: Open Targets association 0.66 with myeloproliferative neoplasm (MONDO_0020076); Breast cancer: Open Targets association 0.64 with breast cancer (MONDO_0007254); Ovarian cancer: Open Targets association 0.62 with ovarian cancer (MONDO_0008170); Skin cancer: Open Targets association 0.56 with skin cancer (MONDO_0002898); Lung cancer: Open Targets association 0.53 with lung cancer (MONDO_0008903)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword "DNA repair". Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3585: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3585
- UniProt Q9BXW9: https://www.uniprot.org/uniprotkb/Q9BXW9/entry
- NCBI Gene 2177: https://www.ncbi.nlm.nih.gov/gene/2177
- Ensembl ENSG00000144554: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000144554

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Acute myeloid leukaemia](https://onco.cc/cancers/aml/), [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Melanoma](https://onco.cc/cancers/melanoma/), [Myeloproliferative neoplasms (PV, ET, myelofibrosis)](https://onco.cc/cancers/myeloproliferative-neoplasms/), [Ovarian cancer](https://onco.cc/cancers/ovarian/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/fancd2.json