# FANCE

Source: https://onco.cc/targets/fance/  
OnCo record `fance` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FANCE (Fanconi anaemia group E protein) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Leukaemia, Colorectal cancer, Myeloproliferative neoplasms and 2 more.

## Summary

As part of the Fanconi anaemia (FA) complex functions in DNA cross-links repair. Required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2.

Open Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes literature 0.81, genetic association 0.74, somatic mutation 0.95, genetic literature 0.83).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: FA complementation group E; Fanconi anemia group E protein
- Tags: cancer-genes-wave
- Symbol: FANCE
- Class: other
- Biology: As part of the Fanconi anaemia (FA) complex functions in DNA cross-links repair. Required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2. Location: Nucleus (UniProt). Locus 6p21.31 (HGNC).
- Where found: Leukaemia: Open Targets association 0.62 with leukaemia (MONDO_0005059); Colorectal cancer: Open Targets association 0.54 with colorectal cancer (MONDO_0005575); Myeloproliferative neoplasms: Open Targets association 0.53 with myeloproliferative neoplasm (MONDO_0020076); Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898); Acute myeloid leukaemia: Open Targets association 0.53 with acute myeloid leukaemia (MONDO_0018874)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword "DNA repair". Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3586: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3586
- UniProt Q9HB96: https://www.uniprot.org/uniprotkb/Q9HB96/entry
- NCBI Gene 2178: https://www.ncbi.nlm.nih.gov/gene/2178
- Ensembl ENSG00000112039: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000112039

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Acute myeloid leukaemia](https://onco.cc/cancers/aml/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Myeloproliferative neoplasms (PV, ET, myelofibrosis)](https://onco.cc/cancers/myeloproliferative-neoplasms/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/fance.json