# FANCF

Source: https://onco.cc/targets/fancf/  
OnCo record `fancf` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FANCF (Fanconi anaemia group F protein) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Leukaemia, Skin cancer and Melanoma.

## Summary

DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.

Open Targets scores its association with cancer at 0.73 (direct and indirect evidence; datatypes genetic literature 0.83, affected pathway 0.26, literature 0.94, genetic association 0.25, somatic mutation 0.93, animal model 0.49).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: FA complementation group F; Fanconi anemia group F protein
- Tags: cancer-genes-wave
- Symbol: FANCF
- Class: other
- Biology: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Location: Nucleus (UniProt). Locus 11p14.3 (HGNC).
- Where found: Leukaemia: Open Targets association 0.60 with leukaemia (MONDO_0005059); Skin cancer: Open Targets association 0.50 with skin cancer (MONDO_0002898); Melanoma: Open Targets association 0.51 with melanoma (MONDO_0005105)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword "DNA repair". Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3587: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3587
- UniProt Q9NPI8: https://www.uniprot.org/uniprotkb/Q9NPI8/entry
- NCBI Gene 2188: https://www.ncbi.nlm.nih.gov/gene/2188
- Ensembl ENSG00000183161: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000183161

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Melanoma](https://onco.cc/cancers/melanoma/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/fancf.json