# FANCG

Source: https://onco.cc/targets/fancg/  
OnCo record `fancg` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FANCG (Fanconi anaemia group G protein) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Leukaemia, Myeloproliferative neoplasms, Colorectal cancer and 2 more.

## Summary

DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumour suppressor gene.

Open Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes genetic literature 0.83, literature 0.90, genetic association 0.60, somatic mutation 0.96, animal model 0.35).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: FA complementation group G; Fanconi anemia group G protein; XRCC9
- Tags: cancer-genes-wave
- Symbol: FANCG
- Class: other
- Biology: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumour suppressor gene. Location: Nucleus; Cytoplasm (UniProt). Locus 9p13.3 (HGNC).
- Where found: Leukaemia: Open Targets association 0.62 with leukaemia (MONDO_0005059); Myeloproliferative neoplasms: Open Targets association 0.54 with myeloproliferative neoplasm (MONDO_0020076); Colorectal cancer: Open Targets association 0.52 with colorectal cancer (MONDO_0005575); Lung cancer: Open Targets association 0.51 with lung cancer (MONDO_0008903); Acute myeloid leukaemia: Open Targets association 0.54 with acute myeloid leukaemia (MONDO_0018874)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword "DNA repair". Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3588: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3588
- UniProt O15287: https://www.uniprot.org/uniprotkb/O15287/entry
- NCBI Gene 2189: https://www.ncbi.nlm.nih.gov/gene/2189
- Ensembl ENSG00000221829: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000221829

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Acute myeloid leukaemia](https://onco.cc/cancers/aml/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Myeloproliferative neoplasms (PV, ET, myelofibrosis)](https://onco.cc/cancers/myeloproliferative-neoplasms/)

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JSON: https://onco.cc/api/v1/entities/fancg.json