# FANCI

Source: https://onco.cc/targets/fanci/  
OnCo record `fanci` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FANCI (Fanconi anaemia group I protein) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.

## Summary

Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA. Participates in S phase and G2 phase checkpoint activation upon DNA damage.

Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.96, affected pathway 0.30, genetic association 0.50, genetic literature 0.83).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: FA complementation group I; Fanconi anemia group I protein; FLJ10719; KIAA1794
- Tags: cancer-genes-wave
- Symbol: FANCI
- Class: other
- Biology: Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. The FANCI-FANCD2 complex binds and scans double-stranded DNA (dsDNA) for DNA damage; this complex stalls at DNA junctions between double-stranded DNA and single-stranded DNA. Participates in S phase and G2 phase checkpoint activation upon DNA damage. Location: Nucleus; Cytoplasm (UniProt). Locus 15q26.1 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword "DNA repair". Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:25568: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25568
- UniProt Q9NVI1: https://www.uniprot.org/uniprotkb/Q9NVI1/entry
- NCBI Gene 55215: https://www.ncbi.nlm.nih.gov/gene/55215
- Ensembl ENSG00000140525: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000140525

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/fanci.json