# FANCM

Source: https://onco.cc/targets/fancm/  
OnCo record `fancm` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FANCM (Fanconi anaemia group M protein) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Breast cancer and Ovarian cancer.

## Summary

DNA-dependent ATPase component of the Fanconi anaemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates.

Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes genetic literature 0.33, affected pathway 0.31, literature 0.67, genetic association 0.88, animal model 0.44).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: FA complementation group M; Fanconi anemia group M protein; FAAP250; KIAA1596
- Tags: cancer-genes-wave
- Symbol: FANCM
- Class: enzyme
- Biology: DNA-dependent ATPase component of the Fanconi anaemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX. In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates. Location: Nucleus (UniProt). Locus 14q21.2 (HGNC).
- Where found: Breast cancer: Open Targets association 0.55 with breast cancer (MONDO_0007254); Ovarian cancer: Open Targets association 0.53 with ovarian cancer (MONDO_0008170)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword "DNA repair". Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:23168: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23168
- UniProt Q8IYD8: https://www.uniprot.org/uniprotkb/Q8IYD8/entry
- NCBI Gene 57697: https://www.ncbi.nlm.nih.gov/gene/57697
- Ensembl ENSG00000187790: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000187790

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Ovarian cancer](https://onco.cc/cancers/ovarian/)

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JSON: https://onco.cc/api/v1/entities/fancm.json