# FAST-02 (proton FLASH for thoracic bone metastases)

Source: https://onco.cc/trials/fast-02/  
OnCo record `fast-02` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

The second human study of ultra-fast proton radiotherapy, this time for painful bone metastases in the chest wall, close to the lungs and heart. Ten patients were treated with no moderate or worse side effects.

## Summary

FAST-02 enrolled 12 patients and treated 10 with single-fraction proton FLASH to the rib or scapula. Average time on the table was 14.6 minutes. At a median follow-up of 189 days there were no grade 2 or worse acute or late adverse events at least possibly related to FLASH; pain responded completely in six and partly in three, and three patients reported pain flares. The registry lists the study as active, not recruiting.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-11-04
- Also known as: FAST-02 trial
- Tags: machines-wave3
- Registry id: NCT05524064
- Phase: not-applicable
- Setting: Adults with one to three painful non-vertebral bone metastases in the rib or scapula, treated with 8 Gy proton FLASH at 40 Gy per second or more, under FDA investigational device exemption G220086
- Sponsor: Varian, a Siemens Healthineers Company
- Enrolled: 12
- Result: No grade 2 or worse FLASH-related adverse events in 10 treated patients; complete pain response in 6.

## Sources

- ClinicalTrials.gov NCT05524064: https://clinicaltrials.gov/study/NCT05524064
- Daugherty et al., FAST-02: proton FLASH for thoracic bone metastases (Radiotherapy and Oncology 2026): https://doi.org/10.1016/j.radonc.2026.111671

## Connected records

- technologies: [FLASH radiotherapy](https://onco.cc/technologies/flash-rt/), [FLASH research accelerators (Oriatron, Mobetron FLASH, ProBeam FLASH)](https://onco.cc/technologies/flash-research-accelerators/), [Proton therapy machines: cyclotrons, synchrotrons and single-room systems](https://onco.cc/technologies/proton-therapy-systems/)
- companies: [Varian (Siemens Healthineers)](https://onco.cc/companies/varian/)
- terms: [Bone metastases and skeletal-related events](https://onco.cc/terms/bone-metastases/)
- trials: [FAST-01 (proton FLASH for bone metastases)](https://onco.cc/trials/fast-01/)
- roadmaps: [Particle therapy machines: from Loma Linda to proton rooms in a linac vault, carbon gantries and FLASH](https://onco.cc/roadmaps/particle-therapy-machines-roadmap/)

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