# FAT2

Source: https://onco.cc/targets/fat2/  
OnCo record `fat2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FAT2 (Protocadherin Fat 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Vulvar cancer.

## Summary

Involved in the regulation of cell migration. May be involved in mediating the organisation of the parallel fibres of granule cells during cerebellar development.

IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Vulva/Vagina.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: FAT atypical cadherin 2; Protocadherin Fat 2; MEGF1; CDHF8; HFAT2; CDHR9
- Tags: cancer-genes-wave
- Symbol: FAT2
- Class: tumor-suppressor
- Biology: Involved in the regulation of cell migration. May be involved in mediating the organisation of the parallel fibres of granule cells during cerebellar development. Location: Cell membrane; Cell junction; Golgi apparatus, trans-Golgi network (UniProt). Locus 5q33.1 (HGNC).
- Where found: Vulvar cancer: IntOGen driver in 1 cohort (VULVA)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3596: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3596
- UniProt Q9NYQ8: https://www.uniprot.org/uniprotkb/Q9NYQ8/entry
- NCBI Gene 2196: https://www.ncbi.nlm.nih.gov/gene/2196
- Ensembl ENSG00000086570: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000086570

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Vulvar cancer](https://onco.cc/cancers/vulvar/)

---
JSON: https://onco.cc/api/v1/entities/fat2.json