# FAT3

Source: https://onco.cc/targets/fat3/  
OnCo record `fat3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FAT3 (Protocadherin Fat 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Pancreatic ductal adenocarcinoma, Renal cell carcinoma and 5 more.

## Summary

May play a role in the interactions between neurites derived from specific subsets of neurons during development.

IntOGen calls it a driver in 29 cohorts (22 activating, 7 loss-of-function), covering Angiosarcoma, Invasive Breast Carcinoma, Renal Clear Cell Carcinoma, Cholangiocarcinoma, Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma, Colon Adenocarcinoma and others.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: FAT atypical cadherin 3; Protocadherin Fat 3; KIAA1989; CDHF15; CDHR10
- Tags: cancer-genes-wave
- Symbol: FAT3
- Class: oncogene
- Biology: May play a role in the interactions between neurites derived from specific subsets of neurons during development. Location: Membrane (UniProt). Locus 11q14.3 (HGNC).
- Where found: Breast cancer: IntOGen driver in 4 cohorts (BRCA); Pancreatic ductal adenocarcinoma: IntOGen driver in 3 cohorts (PAAD, PANCREAS); Renal cell carcinoma: IntOGen driver in 2 cohorts (CCRCC, RCC); Colorectal cancer: IntOGen driver in 2 cohorts (COAD, COADREAD); Prostate cancer: IntOGen driver in 2 cohorts (PRAD); Gastric & gastro-oesophageal junction cancer: IntOGen driver in 2 cohorts (STAD, STOMACH)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 22 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 7 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:23112: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23112
- UniProt Q8TDW7: https://www.uniprot.org/uniprotkb/Q8TDW7/entry
- NCBI Gene 120114: https://www.ncbi.nlm.nih.gov/gene/120114
- Ensembl ENSG00000165323: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000165323

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/), [Head and neck squamous cell carcinoma](https://onco.cc/cancers/head-and-neck/), [Neuroendocrine tumours](https://onco.cc/cancers/neuroendocrine/), [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/), [Prostate cancer](https://onco.cc/cancers/prostate/), [Renal cell carcinoma](https://onco.cc/cancers/rcc/)

---
JSON: https://onco.cc/api/v1/entities/fat3.json