# FBXW11

Source: https://onco.cc/targets/fbxw11/  
OnCo record `fbxw11` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FBXW11 (F-box/WD repeat-containing protein 11) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.

## Summary

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognises and binds to phosphorylated target proteins: the interaction with substrates requires the phosphorylation of the two serine residues in the substrates' destruction motif D-S-G-X(2,3,4)-S. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signalling regulation.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: F-box and WD repeat domain containing 11; F-box/WD repeat-containing protein 11; KIAA0696; Fbw1b; BTRCP2; BTRC2; Hos; Fbw11; FBXW1B
- Tags: cancer-genes-wave
- Symbol: FBXW11
- Class: other
- Biology: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognises and binds to phosphorylated target proteins: the interaction with substrates requires the phosphorylation of the two serine residues in the substrates' destruction motif D-S-G-X(2,3,4)-S. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signalling regulation. SCF(FBXW11) plays a key role in NF-kappa-B activation by mediating ubiquitination of phosphorylated NFKBIA, leading to its degradation by the proteasome, thereby allowing the associated NF-kappa-B complex to translocate into the nucleus and to activate transcription. The SCF(FBXW11) complex also regulates NF-kappa-B by mediating ubiquitination of phosphorylated NFKB1: specifically ubiquitinates the p105 form of NFKB1, leading to its degradation. SCF(FBXW11) mediates the ubiquitination of IFNAR1. Location: Cytoplasm; Nucleus (UniProt). Locus 5q35.1 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Salivary Gland Basal Cell Adenoma.

## Sources

- HGNC HGNC:13607: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13607
- UniProt Q9UKB1: https://www.uniprot.org/uniprotkb/Q9UKB1/entry
- NCBI Gene 23291: https://www.ncbi.nlm.nih.gov/gene/23291
- Ensembl ENSG00000072803: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000072803

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)

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JSON: https://onco.cc/api/v1/entities/fbxw11.json