# FCGR2A

Source: https://onco.cc/targets/fcgr2a/  
OnCo record `fcgr2a` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FCGR2A (Low affinity immunoglobulin gamma Fc region receptor II-a) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer and HER2-positive breast cancer.

## Summary

Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens.

CIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Trastuzumab.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: Fc gamma receptor IIa; Low affinity immunoglobulin gamma Fc region receptor II-a; CD32; CD32A; IGFR2; CDw32; Fc-gamma-RIIa; FcgammaRIIa; FCG2; FCGR2A1; FCGR2
- Tags: cancer-genes-wave
- Symbol: FCGR2A
- Class: other
- Biology: Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonised antigens. Location: Cell membrane (UniProt). Locus 1q23.3 (HGNC).
- Where found: Breast cancer: CIViC evidence names this disease; HER2-positive breast cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3616: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3616
- UniProt P12318: https://www.uniprot.org/uniprotkb/P12318/entry
- NCBI Gene 2212: https://www.ncbi.nlm.nih.gov/gene/2212
- Ensembl ENSG00000143226: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000143226

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [HER2-positive breast cancer](https://onco.cc/cancers/breast-her2-positive/)

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JSON: https://onco.cc/api/v1/entities/fcgr2a.json