# FCRL4

Source: https://onco.cc/targets/fcrl4/  
OnCo record `fcrl4` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FCRL4 (Fc receptor-like protein 4) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma, Skin cancer, Lung cancer and 2 more.

## Summary

May function as an inhibitor of the B-cell receptor signalling. May function in the B-cell-mediated immune response.

Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.39, genetic association 0.00, somatic mutation 0.83). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Pancreatic Adenocarcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: Fc receptor like 4; Fc receptor-like protein 4; FCRH4; IRTA1; IGFP2; CD307d
- Tags: cancer-genes-wave
- Symbol: FCRL4
- Class: tumor-suppressor
- Biology: May function as an inhibitor of the B-cell receptor signalling. May function in the B-cell-mediated immune response. Location: Cell membrane (UniProt). Locus 1q23.1 (HGNC).
- Where found: Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD); Skin cancer: Open Targets association 0.56 with skin cancer (MONDO_0002898); Lung cancer: Open Targets association 0.54 with lung cancer (MONDO_0008903); Breast cancer: Open Targets association 0.51 with breast cancer (MONDO_0007254); Melanoma: Open Targets association 0.55 with melanoma (MONDO_0005105)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:18507: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18507
- UniProt Q96PJ5: https://www.uniprot.org/uniprotkb/Q96PJ5/entry
- NCBI Gene 83417: https://www.ncbi.nlm.nih.gov/gene/83417
- Ensembl ENSG00000163518: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000163518

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Melanoma](https://onco.cc/cancers/melanoma/), [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/fcrl4.json