# FDPS

Source: https://onco.cc/targets/fdps/  
OnCo record `fdps` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FDPS (Farnesyl pyrophosphate synthase) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Prostate cancer, Multiple myeloma and Breast cancer.

## Summary

Key enzyme in isoprenoid biosynthesis which catalyses the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyses the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.

Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.86, genetic association 0.00, clinical 0.99).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: farnesyl diphosphate synthase; Farnesyl pyrophosphate synthase
- Tags: cancer-genes-wave
- Symbol: FDPS
- Class: enzyme
- Biology: Key enzyme in isoprenoid biosynthesis which catalyses the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyses the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. Location: Cytoplasm (UniProt). Locus 1q22 (HGNC).
- Where found: Prostate cancer: Open Targets association 0.60 with prostate cancer (MONDO_0008315); Multiple myeloma: Open Targets association 0.60 with plasma cell myeloma (MONDO_0009693); Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.99. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3631: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3631
- UniProt P14324: https://www.uniprot.org/uniprotkb/P14324/entry
- NCBI Gene 2224: https://www.ncbi.nlm.nih.gov/gene/2224
- Ensembl ENSG00000160752: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000160752

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Multiple myeloma](https://onco.cc/cancers/multiple-myeloma/), [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/fdps.json