# FGB

Source: https://onco.cc/targets/fgb/  
OnCo record `fgb` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FGB (Fibrinogen beta chain) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.

## Summary

Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerise to form an insoluble fibrin matrix. Fibrin has a major function in haemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilise the lesion and guide cell migration during re-epithelialisation.

Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.72, affected pathway 0.97, genetic association 0.02, clinical 0.43).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: fibrinogen beta chain; Fibrinogen beta chain
- Tags: cancer-genes-wave
- Symbol: FGB
- Class: other
- Biology: Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerise to form an insoluble fibrin matrix. Fibrin has a major function in haemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilise the lesion and guide cell migration during re-epithelialisation. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Location: Secreted (UniProt). Locus 4q31.3 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.43. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3662: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3662
- UniProt P02675: https://www.uniprot.org/uniprotkb/P02675/entry
- NCBI Gene 2244: https://www.ncbi.nlm.nih.gov/gene/2244
- Ensembl ENSG00000171564: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000171564

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/fgb.json