# FGD1

Source: https://onco.cc/targets/fgd1/  
OnCo record `fgd1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FGD1 (FYVE, RhoGEF and PH domain-containing protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer.

## Summary

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape.

IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Prostate Adenocarcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: FYVE, RhoGEF and PH domain containing 1; FYVE, RhoGEF and PH domain-containing protein 1; ZFYVE3
- Tags: cancer-genes-wave
- Symbol: FGD1
- Class: oncogene
- Biology: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Location: Cytoplasm; Cell projection, lamellipodium; Cell projection, ruffle; Cytoplasm, cytoskeleton (UniProt). Locus Xp11.22 (HGNC).
- Where found: Prostate cancer: IntOGen driver in 1 cohort (PRAD)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3663: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3663
- UniProt P98174: https://www.uniprot.org/uniprotkb/P98174/entry
- NCBI Gene 2245: https://www.ncbi.nlm.nih.gov/gene/2245
- Ensembl ENSG00000102302: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000102302

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/fgd1.json