# FGD5

Source: https://onco.cc/targets/fgd5/  
OnCo record `fgd5` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FGD5 (FYVE, RhoGEF and PH domain-containing protein 5) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia.

## Summary

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation.

IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Acute Myeloid Leukaemia.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: FYVE, RhoGEF and PH domain containing 5; FYVE, RhoGEF and PH domain-containing protein 5; ZFYVE23; FLJ39957; FLJ00274
- Tags: cancer-genes-wave
- Symbol: FGD5
- Class: oncogene
- Biology: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. Location: Cytoplasm, cytoskeleton; Cell projection, ruffle membrane; Endoplasmic reticulum; Golgi apparatus (UniProt). Locus 3p25.1 (HGNC).
- Where found: Acute myeloid leukaemia: IntOGen driver in 1 cohort (AML)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:19117: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19117
- UniProt Q6ZNL6: https://www.uniprot.org/uniprotkb/Q6ZNL6/entry
- NCBI Gene 152273: https://www.ncbi.nlm.nih.gov/gene/152273
- Ensembl ENSG00000154783: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000154783

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Acute myeloid leukaemia](https://onco.cc/cancers/aml/)

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JSON: https://onco.cc/api/v1/entities/fgd5.json