# FGF16

Source: https://onco.cc/targets/fgf16/  
OnCo record `fgf16` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FGF16 (Fibroblast growth factor 16) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development.

Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.86, affected pathway 0.98).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: fibroblast growth factor 16; Fibroblast growth factor 16; MF4
- Tags: cancer-genes-wave
- Symbol: FGF16
- Class: other
- Biology: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development. Location: Secreted (UniProt). Locus Xq21.1 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3672: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3672
- UniProt O43320: https://www.uniprot.org/uniprotkb/O43320/entry
- NCBI Gene 8823: https://www.ncbi.nlm.nih.gov/gene/8823
- Ensembl ENSG00000196468: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000196468

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/fgf16.json