# FGF19

Source: https://onco.cc/targets/fgf19/  
OnCo record `fgf19` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FGF19 (Fibroblast growth factor 19) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma and Ovarian cancer.

## Summary

Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.

CIViC holds 5 clinical evidence items and 0 assertions across 4 variants, naming Sorafenib, FGFR4 Inhibitor H3B-6527 and Fisogatinib.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: fibroblast growth factor 19; Fibroblast growth factor 19
- Tags: cancer-genes-wave
- Symbol: FGF19
- Class: other
- Biology: Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. Location: Secreted (UniProt). Locus 11q13.3 (HGNC).
- Where found: Hepatocellular carcinoma: CIViC evidence names this disease; Ovarian cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 3 therapies; CIViC holds 5 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3675: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3675
- UniProt O95750: https://www.uniprot.org/uniprotkb/O95750/entry
- NCBI Gene 9965: https://www.ncbi.nlm.nih.gov/gene/9965
- Ensembl ENSG00000162344: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000162344

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Hepatocellular carcinoma](https://onco.cc/cancers/hcc/), [Ovarian cancer](https://onco.cc/cancers/ovarian/)
- trials: [A Phase Ib/II Trial to Evaluate the Efficacy and Safety of HH-009 for the Treatment of FGF19-positive Advanced or Unresectable HCC](https://onco.cc/trials/nct07547553/), [ABSK-011+BSC vs. Placebo+BSC in Previously Treated Advanced HCC With FGF19 Overexpression](https://onco.cc/trials/nct07327034/)

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JSON: https://onco.cc/api/v1/entities/fgf19.json