# FGF2

Source: https://onco.cc/targets/fgf2/  
OnCo record `fgf2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FGF2 (Fibroblast growth factor 2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Acute myeloid leukaemia.

## Summary

Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signalling. Binds to integrin ITGAV:ITGB3.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Quizartinib. Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes clinical 0.62, affected pathway 0.99, literature 0.99, genetic association 0.00, animal model 0.55).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: fibroblast growth factor 2; Fibroblast growth factor 2
- Tags: cancer-genes-wave
- Symbol: FGF2
- Class: other
- Biology: Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signalling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Location: Secreted; Nucleus (UniProt). Locus 4q28.1 (HGNC).
- Where found: Acute myeloid leukaemia: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.62; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3676: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3676
- UniProt P09038: https://www.uniprot.org/uniprotkb/P09038/entry
- NCBI Gene 2247: https://www.ncbi.nlm.nih.gov/gene/2247
- Ensembl ENSG00000138685: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000138685

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Acute myeloid leukaemia](https://onco.cc/cancers/aml/)
- pathways: [The angiogenic switch & tumour vessels](https://onco.cc/pathways/angiogenic-switch/)

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JSON: https://onco.cc/api/v1/entities/fgf2.json