# FGF22

Source: https://onco.cc/targets/fgf22/  
OnCo record `fgf22` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FGF22 (Fibroblast growth factor 22) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development.

Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.36, affected pathway 0.97, genetic association 0.00).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: fibroblast growth factor 22; Fibroblast growth factor 22
- Tags: cancer-genes-wave
- Symbol: FGF22
- Class: other
- Biology: Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development. Location: Secreted (UniProt). Locus 19p13.3 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3679: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3679
- UniProt Q9HCT0: https://www.uniprot.org/uniprotkb/Q9HCT0/entry
- NCBI Gene 27006: https://www.ncbi.nlm.nih.gov/gene/27006
- Ensembl ENSG00000070388: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000070388

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/fgf22.json