# FGF23

Source: https://onco.cc/targets/fgf23/  
OnCo record `fgf23` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FGF23 (Fibroblast growth factor 23) is a protein on the cell surface. The public catalogues list it as a drug target and an antigen, and an approved or late-stage drug is recorded against it.

## Summary

Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Up-regulates EGR1 expression in the presence of KL.

Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.90, affected pathway 0.98, animal model 0.53). In OnCo, 1 product record names it (Burosumab).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: fibroblast growth factor 23; Fibroblast growth factor 23
- Tags: cancer-genes-wave
- Symbol: FGF23
- Class: surface-antigen
- Biology: Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Up-regulates EGR1 expression in the presence of KL. Acts directly on the parathyroid to decrease PTH secretion. Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralisation. Location: Secreted (UniProt). Locus 12p13.32 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: 1 OnCo product record names it; a membrane or secreted protein (UniProt keywords) that 1 antibody-based OnCo product name. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3680: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3680
- UniProt Q9GZV9: https://www.uniprot.org/uniprotkb/Q9GZV9/entry
- NCBI Gene 8074: https://www.ncbi.nlm.nih.gov/gene/8074
- Ensembl ENSG00000118972: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000118972

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- drugs: [Burosumab](https://onco.cc/drugs/burosumab/)
- pathways: [FGF / FGFR signalling](https://onco.cc/pathways/fgfr-signalling/)

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JSON: https://onco.cc/api/v1/entities/fgf23.json