# FGF3

Source: https://onco.cc/targets/fgf3/  
OnCo record `fgf3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FGF3 (Fibroblast growth factor 3) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer and Hepatocellular carcinoma.

## Summary

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development.

CIViC holds 3 clinical evidence items and 0 assertions across 1 variant, naming Sorafenib and Dovitinib. Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.49, affected pathway 0.92, animal model 0.25, genetic association 0.13).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: fibroblast growth factor 3; Fibroblast growth factor 3; HBGF-3; INT2
- Tags: cancer-genes-wave
- Symbol: FGF3
- Class: other
- Biology: Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development. Location: Secreted (UniProt). Locus 11q13.3 (HGNC).
- Where found: Breast cancer: CIViC evidence names this disease; Hepatocellular carcinoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 3 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3681: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3681
- UniProt P11487: https://www.uniprot.org/uniprotkb/P11487/entry
- NCBI Gene 2248: https://www.ncbi.nlm.nih.gov/gene/2248
- Ensembl ENSG00000186895: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000186895

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Hepatocellular carcinoma](https://onco.cc/cancers/hcc/)

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JSON: https://onco.cc/api/v1/entities/fgf3.json