# FGF4

Source: https://onco.cc/targets/fgf4/  
OnCo record `fgf4` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FGF4 (Fibroblast growth factor 4) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.

## Summary

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis. May play a role in embryonic molar tooth bud development via inducing the expression of MSX1, MSX2 and MSX1-mediated expression of SDC1 in dental mesenchyme cells.

CIViC holds 4 clinical evidence items and 0 assertions across 2 variants, naming Sorafenib. Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.40, affected pathway 0.94, genetic association 0.05).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: fibroblast growth factor 4; Fibroblast growth factor 4; K-FGF; HBGF-4; HST-1; HSTF1
- Tags: cancer-genes-wave
- Symbol: FGF4
- Class: other
- Biology: Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis. May play a role in embryonic molar tooth bud development via inducing the expression of MSX1, MSX2 and MSX1-mediated expression of SDC1 in dental mesenchyme cells. Location: Secreted (UniProt). Locus 11q13.3 (HGNC).
- Where found: Hepatocellular carcinoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 4 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3682: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3682
- UniProt P08620: https://www.uniprot.org/uniprotkb/P08620/entry
- NCBI Gene 2249: https://www.ncbi.nlm.nih.gov/gene/2249
- Ensembl ENSG00000075388: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000075388

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Hepatocellular carcinoma](https://onco.cc/cancers/hcc/)

---
JSON: https://onco.cc/api/v1/entities/fgf4.json