# FGF8

Source: https://onco.cc/targets/fgf8/  
OnCo record `fgf8` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FGF8 (Fibroblast growth factor 8) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system.

Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.92, affected pathway 0.98, animal model 0.30, genetic association 0.00).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: fibroblast growth factor 8; Fibroblast growth factor 8
- Tags: cancer-genes-wave
- Symbol: FGF8
- Class: other
- Biology: Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells. Location: Secreted (UniProt). Locus 10q24.32 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3686: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3686
- UniProt P55075: https://www.uniprot.org/uniprotkb/P55075/entry
- NCBI Gene 2253: https://www.ncbi.nlm.nih.gov/gene/2253
- Ensembl ENSG00000107831: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000107831

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/fgf8.json