# FIP1L1

Source: https://onco.cc/targets/fip1l1/  
OnCo record `fip1l1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FIP1L1 (Pre-mRNA 3'-end-processing factor FIP1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognising the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site.

Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.70, affected pathway 0.76, genetic association 0.09, somatic mutation 0.50).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: factor interacting with PAPOLA and CPSF1; Pre-mRNA 3'-end-processing factor FIP1; DKFZp586K0717; FIP1; hFip1
- Tags: cancer-genes-wave
- Symbol: FIP1L1
- Class: other
- Biology: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognising the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. Location: Nucleus (UniProt). Locus 4q12 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:19124: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19124
- UniProt Q6UN15: https://www.uniprot.org/uniprotkb/Q6UN15/entry
- NCBI Gene 81608: https://www.ncbi.nlm.nih.gov/gene/81608
- Ensembl ENSG00000145216: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000145216

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/fip1l1.json