# FLG

Source: https://onco.cc/targets/flg/  
OnCo record `flg` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FLG (Filaggrin) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Mesothelioma, Acute myeloid leukaemia and 2 more.

## Summary

Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.

Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.91, animal model 0.57, genetic association 0.76, somatic mutation 0.17). IntOGen calls it a driver in 2 cohorts (2 activating, 0 loss-of-function), covering Acute Myeloid Leukaemia, Pleural Mesothelioma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: filaggrin; Filaggrin; FLG1; FLG-1
- Tags: cancer-genes-wave
- Symbol: FLG
- Class: oncogene
- Biology: Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. Location: Cytoplasmic granule (UniProt). Locus 1q21.3 (HGNC).
- Where found: Skin cancer: Open Targets association 0.63 with skin cancer (MONDO_0002898); Mesothelioma: IntOGen driver in 1 cohort (PLMESO); Acute myeloid leukaemia: IntOGen driver in 1 cohort (AML); Pleural mesothelioma: IntOGen driver in 1 cohort (PLMESO); Melanoma: Open Targets association 0.55 with melanoma (MONDO_0005105)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3748: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3748
- UniProt P20930: https://www.uniprot.org/uniprotkb/P20930/entry
- NCBI Gene 2312: https://www.ncbi.nlm.nih.gov/gene/2312
- Ensembl ENSG00000143631: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000143631

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Acute myeloid leukaemia](https://onco.cc/cancers/aml/), [Melanoma](https://onco.cc/cancers/melanoma/), [Mesothelioma](https://onco.cc/cancers/mesothelioma/), [Pleural mesothelioma](https://onco.cc/cancers/pleural-mesothelioma/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/flg.json