# FLT3LG

Source: https://onco.cc/targets/flt3lg/  
OnCo record `flt3lg` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FLT3LG (Fms-related tyrosine kinase 3 ligand) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Acute myeloid leukaemia.

## Summary

Stimulates the proliferation of early haematopoietic cells by activating FLT3. Synergises well with a number of other colony stimulating factors and interleukins. Required for the development of B cells, and dendritic cells (DCs).

CIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Crenolanib, Ponatinib, Sunitinib and Lestaurtinib and others. Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.82, affected pathway 0.83, animal model 0.41, genetic association 0.00).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: fms related receptor tyrosine kinase 3 ligand; Fms-related tyrosine kinase 3 ligand
- Tags: cancer-genes-wave
- Symbol: FLT3LG
- Class: other
- Biology: Stimulates the proliferation of early haematopoietic cells by activating FLT3. Synergises well with a number of other colony stimulating factors and interleukins. Required for the development of B cells, and dendritic cells (DCs). Location: Cell membrane; Secreted (UniProt). Locus 19q13.33 (HGNC).
- Where found: Acute myeloid leukaemia: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 11 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3766: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3766
- UniProt P49771: https://www.uniprot.org/uniprotkb/P49771/entry
- NCBI Gene 2323: https://www.ncbi.nlm.nih.gov/gene/2323
- Ensembl ENSG00000090554: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000090554

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Acute myeloid leukaemia](https://onco.cc/cancers/aml/)

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JSON: https://onco.cc/api/v1/entities/flt3lg.json