# FMN1

Source: https://onco.cc/targets/fmn1/  
OnCo record `fmn1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FMN1 (Formin-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Plays a role in the formation of adherens junction and the polymerisation of linear actin cables.

Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.42, animal model 0.65, genetic association 0.81).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: formin 1; Formin-1; DKFZP686C2281; FLJ45135; MGC125288; MGC125289
- Tags: cancer-genes-wave
- Symbol: FMN1
- Class: other
- Biology: Plays a role in the formation of adherens junction and the polymerisation of linear actin cables. Location: Nucleus; Cytoplasm; Cell junction, adherens junction; Cell membrane (UniProt). Locus 15q13.3 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3768: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3768
- UniProt Q68DA7: https://www.uniprot.org/uniprotkb/Q68DA7/entry
- NCBI Gene 342184: https://www.ncbi.nlm.nih.gov/gene/342184
- Ensembl ENSG00000248905: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000248905

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/fmn1.json