# FN1

Source: https://onco.cc/targets/fn1/  
OnCo record `fn1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FN1 (Fibronectin) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Melanoma.

## Summary

Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonisation, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralisation.

CIViC holds 3 clinical evidence items and 0 assertions across 1 variant, naming L19IL2, Dacarbazine and Daromun. Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 1.00, affected pathway 0.98, genetic association 0.03, clinical 0.19).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: fibronectin 1; Fibronectin; GFND2; lnc-ABCA12-8
- Tags: cancer-genes-wave
- Symbol: FN1
- Class: other
- Biology: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonisation, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralisation. Participates in the regulation of type I collagen deposition by osteoblasts. Acts as a ligand for the LILRB4 receptor, inhibiting FCGR1A/CD64-mediated monocyte activation. Binds fibronectin and induces fibril formation. Location: Secreted, extracellular space, extracellular matrix; Secreted (UniProt). Locus 2q35 (HGNC).
- Where found: Melanoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.19; CIViC holds 3 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3778: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3778
- UniProt P02751: https://www.uniprot.org/uniprotkb/P02751/entry
- NCBI Gene 2335: https://www.ncbi.nlm.nih.gov/gene/2335
- Ensembl ENSG00000115414: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000115414

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Melanoma](https://onco.cc/cancers/melanoma/)

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JSON: https://onco.cc/api/v1/entities/fn1.json