# FNDC3B

Source: https://onco.cc/targets/fndc3b/  
OnCo record `fndc3b` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FNDC3B (Fibronectin type III domain-containing protein 3B) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-Hodgkin lymphoma.

## Summary

May be a positive regulator of adipogenesis.

IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Lymphoid Neoplasm.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: fibronectin type III domain containing 3B; Fibronectin type III domain-containing protein 3B; FAD104; DKFZp762K137; FLJ23399; PRO4979; YVTM2421
- Tags: cancer-genes-wave
- Symbol: FNDC3B
- Class: tumor-suppressor
- Biology: May be a positive regulator of adipogenesis. Location: Membrane (UniProt). Locus 3q26.31 (HGNC).
- Where found: Non-Hodgkin lymphoma: IntOGen driver in 1 cohort (LNM)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:24670: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24670
- UniProt Q53EP0: https://www.uniprot.org/uniprotkb/Q53EP0/entry
- NCBI Gene 64778: https://www.ncbi.nlm.nih.gov/gene/64778
- Ensembl ENSG00000075420: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000075420

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/)

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JSON: https://onco.cc/api/v1/entities/fndc3b.json