# FNTB

Source: https://onco.cc/targets/fntb/  
OnCo record `fntb` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FNTB (Protein farnesyltransferase subunit beta) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.

## Summary

Essential subunit of the farnesyltransferase complex. Catalyses the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Lonafarnib.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: farnesyltransferase, CAAX box, subunit beta; Protein farnesyltransferase subunit beta
- Tags: cancer-genes-wave
- Symbol: FNTB
- Class: enzyme
- Biology: Essential subunit of the farnesyltransferase complex. Catalyses the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Locus 14q23.3 (HGNC).
- Where found: Ovarian cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3785: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3785
- UniProt P49356: https://www.uniprot.org/uniprotkb/P49356/entry
- NCBI Gene 2342: https://www.ncbi.nlm.nih.gov/gene/2342
- Ensembl ENSG00000257365: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000257365

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Ovarian cancer](https://onco.cc/cancers/ovarian/)

---
JSON: https://onco.cc/api/v1/entities/fntb.json