# FoundationOne Germline and FoundationOne Germline More

Source: https://onco.cc/drugs/foundationone-germline/  
OnCo record `foundationone-germline` (Test). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Foundation Medicine's tests of inherited cancer genes from blood or saliva, which can be ordered alongside its tumour profiling: 50 genes, or 154 in the expanded version.

## Summary

Foundation Medicine's page (read 4 November 2026) describes two germline assays: FoundationOne Germline, 50 genes 'identified as high to moderate risk, linked to hereditary cancers that have clear actionability based on clinical guidelines', and FoundationOne Germline More, 154 genes adding 104 'emerging candidate genes associated with lower or uncertain cancer risks'. Both are laboratory-developed tests run by its reference laboratory, Fulgent Genetics, on peripheral blood or a saliva swab, with a typical turnaround of 14 to 21 days, ordered alone or with a comprehensive genomic profiling assay; each needs its own specimen. Billing is handled by Fulgent Genetics.

## Fields

- Kind: Test
- Status: established
- Last checked: 2026-11-04
- Also known as: FoundationOne Germline; FoundationOne Germline More; F1 Germline
- Tags: test; hereditary
- Brand: FoundationOne Germline
- Modality: Germline hereditary cancer sequencing panel (laboratory-developed test)
- Mechanism: Next-generation sequencing of germline DNA from blood or saliva, performed by a reference laboratory: 50 genes, or 154 in the expanded version.

## Sources

- Foundation Medicine: FoundationOne Germline: https://www.foundationmedicine.com/solution/foundationone-germline

## Connected records

- technologies: [Germline (hereditary) testing](https://onco.cc/technologies/germline-testing/)
- companies: [Foundation Medicine (Roche)](https://onco.cc/companies/foundation-medicine/), [Fulgent Genetics](https://onco.cc/companies/fulgent-genetics/)
- terms: [Germline vs somatic mutations](https://onco.cc/terms/germline-vs-somatic/), [Hereditary cancer syndromes](https://onco.cc/terms/hereditary-cancer-syndromes/)

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