# FOXC2

Source: https://onco.cc/targets/foxc2/  
OnCo record `foxc2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FOXC2 (Forkhead box protein C2) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.

## Summary

Transcriptional activator.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Oxaliplatin.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: forkhead box C2; Forkhead box protein C2; MFH-1; FKHL14
- Tags: cancer-genes-wave
- Symbol: FOXC2
- Class: transcription
- Biology: Transcriptional activator. Location: Nucleus (UniProt). Locus 16q24.1 (HGNC).
- Where found: Colorectal cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3801: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3801
- UniProt Q99958: https://www.uniprot.org/uniprotkb/Q99958/entry
- NCBI Gene 2303: https://www.ncbi.nlm.nih.gov/gene/2303
- Ensembl ENSG00000176692: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000176692

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/)

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JSON: https://onco.cc/api/v1/entities/foxc2.json