# FOXE1

Source: https://onco.cc/targets/foxe1/  
OnCo record `foxe1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FOXE1 (Forkhead box protein E1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Thyroid cancer.

## Summary

Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis.

Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.96, animal model 0.91, genetic association 0.71, genetic literature 0.57).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: forkhead box E1; Forkhead box protein E1; TTF-2; HFKH4; FKHL15; TITF2; FOXE2
- Tags: cancer-genes-wave
- Symbol: FOXE1
- Class: transcription
- Biology: Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression. Location: Nucleus (UniProt). Locus 9q22.33 (HGNC).
- Where found: Thyroid cancer: Open Targets association 0.64 with thyroid cancer (MONDO_0002108)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3806: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3806
- UniProt O00358: https://www.uniprot.org/uniprotkb/O00358/entry
- NCBI Gene 2304: https://www.ncbi.nlm.nih.gov/gene/2304
- Ensembl ENSG00000178919: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000178919

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Thyroid cancer](https://onco.cc/cancers/thyroid/)

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JSON: https://onco.cc/api/v1/entities/foxe1.json