# FOXF1

Source: https://onco.cc/targets/foxf1/  
OnCo record `foxf1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FOXF1 (Forkhead box protein F1) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.

## Summary

Probable transcription activator for a number of lung-specific genes.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Bevacizumab.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: forkhead box F1; Forkhead box protein F1; FREAC1; FKHL5
- Tags: cancer-genes-wave
- Symbol: FOXF1
- Class: transcription
- Biology: Probable transcription activator for a number of lung-specific genes. Location: Nucleus (UniProt). Locus 16q24.1 (HGNC).
- Where found: Colorectal cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:3809: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3809
- UniProt Q12946: https://www.uniprot.org/uniprotkb/Q12946/entry
- NCBI Gene 2294: https://www.ncbi.nlm.nih.gov/gene/2294
- Ensembl ENSG00000103241: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000103241

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/)

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JSON: https://onco.cc/api/v1/entities/foxf1.json