# FOXP4

Source: https://onco.cc/targets/foxp4/  
OnCo record `foxp4` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FOXP4 (Forkhead box protein P4) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Transcriptional repressor that represses lung-specific expression.

Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.98, animal model 0.43, genetic association 0.61, somatic mutation 0.28).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: forkhead box P4; Forkhead box protein P4; FLJ40908
- Tags: cancer-genes-wave
- Symbol: FOXP4
- Class: transcription
- Biology: Transcriptional repressor that represses lung-specific expression. Location: Nucleus (UniProt). Locus 6p21.1 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:20842: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20842
- UniProt Q8IVH2: https://www.uniprot.org/uniprotkb/Q8IVH2/entry
- NCBI Gene 116113: https://www.ncbi.nlm.nih.gov/gene/116113
- Ensembl ENSG00000137166: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000137166

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/foxp4.json