# FOXR2

Source: https://onco.cc/targets/foxr2/  
OnCo record `foxr2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FOXR2 (Forkhead box protein R2) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.

## Summary

UniProt has no function text for Q6PJQ5; HGNC names it "forkhead box R2".

CIViC holds 3 clinical evidence items and 2 assertions across 1 variant.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: forkhead box R2; Forkhead box protein R2; MGC21658; FOXN6
- Tags: cancer-genes-wave
- Symbol: FOXR2
- Class: transcription
- Biology: UniProt has no function text for Q6PJQ5; HGNC names it "forkhead box R2". Location: Nucleus (UniProt). Locus Xp11.21 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 3 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: CNS Neuroblastoma With FOXR2 Activation.

## Sources

- HGNC HGNC:30469: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30469
- UniProt Q6PJQ5: https://www.uniprot.org/uniprotkb/Q6PJQ5/entry
- NCBI Gene 139628: https://www.ncbi.nlm.nih.gov/gene/139628
- Ensembl ENSG00000189299: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000189299

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)

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JSON: https://onco.cc/api/v1/entities/foxr2.json