# Francesco Lo-Coco

Source: https://onco.cc/people/francesco-lo-coco/  
OnCo record `francesco-lo-coco` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Italian haematologist who led APL0406, the trial that showed acute promyelocytic leukaemia can be cured with all-trans retinoic acid and arsenic trioxide alone, without chemotherapy.

## Summary

Francesco Lo-Coco was professor of haematology at the University of Rome Tor Vergata and a leading investigator of the Italian GIMEMA group. He was first author of the 2013 New England Journal of Medicine report of APL0406, the Italian-German trial that showed all-trans retinoic acid plus arsenic trioxide was at least as effective as ATRA plus chemotherapy in low- and intermediate-risk acute promyelocytic leukaemia, with far fewer haematological complications. The chemotherapy-free regimen became the standard of care. He died in 2019.

## Fields

- Kind: Person
- Last checked: 2026-09-18
- Tags: leukaemia; trialist
- Role: Haematologist, University of Rome Tor Vergata (died 2019)
- Specialisms: Acute promyelocytic leukaemia; Arsenic trioxide; Molecular monitoring

## Connected records

- cancers: [Acute myeloid leukaemia](https://onco.cc/cancers/aml/), [Acute promyelocytic leukaemia](https://onco.cc/cancers/apl/)
- trials: [APL0406](https://onco.cc/trials/apl0406/)
- key papers: [APL0406: retinoic acid plus arsenic trioxide without chemotherapy for low- and intermediate-risk acute promyelocytic leukaemia](https://onco.cc/key-papers/paper-apl0406-lo-coco-nejm-2013/)

---
JSON: https://onco.cc/api/v1/entities/francesco-lo-coco.json