# Frederick L. Locke

Source: https://onco.cc/people/frederick-locke/  
OnCo record `frederick-locke` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Led the ZUMA-7 trial that put CAR-T ahead of transplant in relapsed large B-cell lymphoma.

## Summary

Frederick L. Locke is Chair of the Department of Blood and Marrow Transplant and Cellular Immunotherapy at Moffitt Cancer Center. He is known for leading the ZUMA-7 trial, which put CAR-T ahead of transplant in relapsed large B-cell lymphoma, and was principal investigator of ZUMA-1 and ZUMA-7 with axicabtagene ciloleucel. His selected paper reports axicabtagene ciloleucel as second-line therapy for large B-cell lymphoma. He is also a leader in CAR-T real-world outcomes and in managing the toxicity of cellular therapy.

## Fields

- Kind: Person
- Last checked: 2026-09-08
- Role: Chair, Department of Blood and Marrow Transplant and Cellular Immunotherapy
- Specialisms: CAR-T therapy; Lymphoma; Cellular therapy toxicity

## Sources

- Moffitt profile: https://www.moffitt.org/providers/frederick-locke/
- PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Locke%20FL%5BAuthor%5D

## Connected records

- cancers: [Diffuse large B-cell lymphoma](https://onco.cc/cancers/dlbcl/)
- technologies: [CAR-T cell therapy](https://onco.cc/technologies/car-t/)
- targets: [CD19](https://onco.cc/targets/cd19/)
- drugs: [Axicabtagene ciloleucel](https://onco.cc/drugs/axicabtagene-ciloleucel/)
- institutions: [Moffitt Cancer Center](https://onco.cc/institutions/moffitt/)
- trials: [ZUMA-7](https://onco.cc/trials/zuma-7/)
- key papers: [ZUMA-1: axicabtagene ciloleucel for refractory large B-cell lymphoma, the first CAR-T approved for lymphoma](https://onco.cc/key-papers/paper-zuma-1-axi-cel-nejm-2017/), [ZUMA-7: axi-cel CAR-T instead of salvage chemotherapy and transplant for large B-cell lymphoma that relapses early](https://onco.cc/key-papers/paper-zuma-7-axi-cel-second-line-nejm-2022/)

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