# FRS2

Source: https://onco.cc/targets/frs2/  
OnCo record `frs2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FRS2 (Fibroblast growth factor receptor substrate 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Adapter protein that links activated FGR and NGF receptors to downstream signalling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signalling via SHC1 by competing for a common binding site on NTRK1.

Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.68, affected pathway 0.90, genetic association 0.00).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: fibroblast growth factor receptor substrate 2; Fibroblast growth factor receptor substrate 2; SNT-1; FRS2alpha; SNT1; FRS2A
- Tags: cancer-genes-wave
- Symbol: FRS2
- Class: other
- Biology: Adapter protein that links activated FGR and NGF receptors to downstream signalling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signalling via SHC1 by competing for a common binding site on NTRK1. Location: Endomembrane system (UniProt). Locus 12q15 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:16971: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16971
- UniProt Q8WU20: https://www.uniprot.org/uniprotkb/Q8WU20/entry
- NCBI Gene 10818: https://www.ncbi.nlm.nih.gov/gene/10818
- Ensembl ENSG00000166225: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000166225

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- pathways: [FGF / FGFR signalling](https://onco.cc/pathways/fgfr-signalling/)

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JSON: https://onco.cc/api/v1/entities/frs2.json