# FRS3

Source: https://onco.cc/targets/frs3/  
OnCo record `frs3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FRS3 (Fibroblast growth factor receptor substrate 3) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Adapter protein that links FGF and NGF receptors to downstream signalling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signalling by interfering with the phosphorylation and nuclear translocation of ERK2.

Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.74, affected pathway 0.76, genetic association 0.23).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: fibroblast growth factor receptor substrate 3; Fibroblast growth factor receptor substrate 3; SNT-2; FRS2beta; FRS2B
- Tags: cancer-genes-wave
- Symbol: FRS3
- Class: other
- Biology: Adapter protein that links FGF and NGF receptors to downstream signalling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signalling by interfering with the phosphorylation and nuclear translocation of ERK2. Location: Membrane (UniProt). Locus 6p21.1 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:16970: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16970
- UniProt O43559: https://www.uniprot.org/uniprotkb/O43559/entry
- NCBI Gene 10817: https://www.ncbi.nlm.nih.gov/gene/10817
- Ensembl ENSG00000137218: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000137218

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/frs3.json