# FUBP1

Source: https://onco.cc/targets/fubp1/  
OnCo record `fubp1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

FUBP1 (Far upstream element-binding protein 1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Skin cancer, Breast cancer, Colorectal cancer and 2 more.

## Summary

Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.72 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.54, somatic mutation 0.77). IntOGen calls it a driver in 4 cohorts (2 activating, 2 loss-of-function), covering Invasive Breast Carcinoma, Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma, Low-Grade Glioma, NOS.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: far upstream element binding protein 1; Far upstream element-binding protein 1
- Tags: cancer-genes-wave
- Symbol: FUBP1
- Class: transcription
- Biology: Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. Location: Nucleus (UniProt). Locus 1p31.1 (HGNC).
- Where found: Skin cancer: Open Targets association 0.61 with skin cancer (MONDO_0002898); Breast cancer: IntOGen driver in 1 cohort (BRCA); Colorectal cancer: Open Targets association 0.54 with colorectal cancer (MONDO_0005575); Lung cancer: Open Targets association 0.50 with lung cancer (MONDO_0008903); Chronic lymphocytic leukaemia: IntOGen driver in 1 cohort (CLLSLL)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Oligodendroglioma; Low-Grade Glioma, NOS.

## Sources

- HGNC HGNC:4004: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4004
- UniProt Q96AE4: https://www.uniprot.org/uniprotkb/Q96AE4/entry
- NCBI Gene 8880: https://www.ncbi.nlm.nih.gov/gene/8880
- Ensembl ENSG00000162613: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000162613

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Chronic lymphocytic leukaemia](https://onco.cc/cancers/cll/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/fubp1.json