# A Multicenter Study of IBI343 Monotherapy Versus Placebo in Subjects With Previously Treated, Claudin (CLDN) 18.2-positive, Pancreatic Cancer(G-HOPE-002)

Source: https://onco.cc/trials/g-hope-002/  
OnCo record `g-hope-002` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial testing IBI343 in pancreatic ductal adenocarcinoma, now recruiting.

## Summary

A Multicenter Study of IBI343 Monotherapy Versus Placebo in Subjects With Previously Treated, Claudin (CLDN) 18.2-positive, Pancreatic Cancer(G-HOPE-002) is a phase 3 interventional study registered as NCT07066098, led by Innovent Biologics (Suzhou), and recruiting on the registry. Official title: A Multicenter, Randomised, Double-Blind, Phase III Study of IBI343 Monotherapy Plus Best Supportive Care Versus Placebo Plus Best Supportive Care in Participants With Claudin (CLDN) 18.2-Positive, Locally Advanced Unresectable or Metastatic Pancreatic Cancer Who Received>=2 Prior Lines of Therapy. Planned enrolment is 201 participants (estimated). The study started in 2025-08-04 and primary completion is expected in 2027-06-30. No results have been posted on ClinicalTrials.gov.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-11
- Also known as: G-HOPE-002
- Tags: ctgov-ingest
- Registry id: NCT07066098
- Phase: 3
- Setting: A Multicenter, Randomized, Double-Blind, Phase III Study of IBI343 Monotherapy Plus Best Supportive Care Versus Placebo Plus Best Supportive Care in Participants With Claudin (CLDN) 18.2-Positive, Locally Advanced Unresectable or Metastatic Pancreatic Cancer Who Received>=2 Prior Lines of Therapy
- Sponsor: Innovent Biologics (Suzhou)
- Enrolled: 201

## Sources

- ClinicalTrials.gov NCT07066098: https://clinicaltrials.gov/study/NCT07066098

## Connected records

- cancers: [Metastatic pancreatic ductal adenocarcinoma](https://onco.cc/cancers/metastatic-pdac/), [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/)
- drugs: [IBI343](https://onco.cc/drugs/ibi343/)
- companies: [Innovent Biologics](https://onco.cc/companies/innovent/)

---
JSON: https://onco.cc/api/v1/entities/g-hope-002.json