# GAB1

Source: https://onco.cc/targets/gab1/  
OnCo record `gab1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

GAB1 (GRB2-associated-binding protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Adapter protein that plays a role in intracellular signalling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signalling. Probably involved in signalling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR).

Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.93, affected pathway 0.82, animal model 0.50, genetic association 0.14).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: GRB2 associated binding protein 1; GRB2-associated-binding protein 1; DFNB26
- Tags: cancer-genes-wave
- Symbol: GAB1
- Class: other
- Biology: Adapter protein that plays a role in intracellular signalling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signalling. Probably involved in signalling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signalling pathway. Locus 4q31.21 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:4066: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4066
- UniProt Q13480: https://www.uniprot.org/uniprotkb/Q13480/entry
- NCBI Gene 2549: https://www.ncbi.nlm.nih.gov/gene/2549
- Ensembl ENSG00000109458: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000109458

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- pathways: [FGF / FGFR signalling](https://onco.cc/pathways/fgfr-signalling/)

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JSON: https://onco.cc/api/v1/entities/gab1.json