# GAB2

Source: https://onco.cc/targets/gab2/  
OnCo record `gab2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

GAB2 (GRB2-associated-binding protein 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia, Myeloproliferative neoplasms and Chronic myeloid leukaemia.

## Summary

Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signalling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signalling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation.

Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.84, animal model 0.41, genetic association 0.47).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: GRB2 associated binding protein 2; GRB2-associated-binding protein 2; KIAA0571
- Tags: cancer-genes-wave
- Symbol: GAB2
- Class: other
- Biology: Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signalling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signalling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and haematopoiesis. Location: Cytoplasm; Cell membrane; Membrane raft (UniProt). Locus 11q14.1 (HGNC).
- Where found: Leukaemia: Open Targets association 0.59 with leukaemia (MONDO_0005059); Myeloproliferative neoplasms: Open Targets association 0.59 with myeloproliferative neoplasm (MONDO_0020076); Chronic myeloid leukaemia: Open Targets association 0.54 with chronic myelogenous leukaemia, BCR-ABL1 positive (MONDO_0011996)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:14458: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14458
- UniProt Q9UQC2: https://www.uniprot.org/uniprotkb/Q9UQC2/entry
- NCBI Gene 9846: https://www.ncbi.nlm.nih.gov/gene/9846
- Ensembl ENSG00000033327: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000033327

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Chronic myeloid leukaemia (CML)](https://onco.cc/cancers/cml/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Myeloproliferative neoplasms (PV, ET, myelofibrosis)](https://onco.cc/cancers/myeloproliferative-neoplasms/)
- pathways: [BCR::ABL1 (Philadelphia chromosome)](https://onco.cc/pathways/bcr-abl1-signalling/), [Chronic myeloid leukaemia (KEGG map)](https://onco.cc/pathways/cml-signalling/)

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JSON: https://onco.cc/api/v1/entities/gab2.json