# GABRG3

Source: https://onco.cc/targets/gabrg3/  
OnCo record `gabrg3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

GABRG3 (Gamma-aminobutyric acid receptor subunit gamma-3) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.

## Summary

Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride across the cell membrane down their electrochemical gradient.

Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.16, genetic association 0.51, clinical 0.66).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: gamma-aminobutyric acid type A receptor subunit gamma3; Gamma-aminobutyric acid receptor subunit gamma-3
- Tags: cancer-genes-wave
- Symbol: GABRG3
- Class: other
- Biology: Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride across the cell membrane down their electrochemical gradient. Location: Postsynaptic cell membrane; Cell membrane (UniProt). Locus 15q12 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.66. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:4088: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4088
- UniProt Q99928: https://www.uniprot.org/uniprotkb/Q99928/entry
- NCBI Gene 2567: https://www.ncbi.nlm.nih.gov/gene/2567
- Ensembl ENSG00000182256: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000182256

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/gabrg3.json