# GADD45A

Source: https://onco.cc/targets/gadd45a/  
OnCo record `gadd45a` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

GADD45A (Growth arrest and DNA damage-inducible protein GADD45 alpha) is a gene. The public catalogues list it as a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.

## Summary

In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: growth arrest and DNA damage inducible alpha; Growth arrest and DNA damage-inducible protein GADD45 alpha; GADD45; DDIT1
- Tags: cancer-genes-wave
- Symbol: GADD45A
- Class: other
- Biology: In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. Location: Nucleus (UniProt). Locus 1p31.3 (HGNC).
- Where found: Ovarian cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants; UniProt keyword "DNA damage". Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:4095: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4095
- UniProt P24522: https://www.uniprot.org/uniprotkb/P24522/entry
- NCBI Gene 1647: https://www.ncbi.nlm.nih.gov/gene/1647
- Ensembl ENSG00000116717: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000116717

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Ovarian cancer](https://onco.cc/cancers/ovarian/)

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JSON: https://onco.cc/api/v1/entities/gadd45a.json